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产品目录

重组人LIR-2图片
产品货号:
JN1842
中文名称:
重组人LIR-2
英文名称:
Recombinant Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2
产品规格:
10μg|50μg|500μg|1mg
发货周期:
1~3天
产品价格:
询价
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Gln22-His458在C端含有His标签。

LIR-2质量控制:>95%(还原性SDS-PAGE)

LIR-2制剂:冻干品

LIR-2保存
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。

LIR-2复溶
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。

关于LIR-2
Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
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